rna polymerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1767	BMH-21	BMH21	DNA/RNA Synthesis
	BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.		DNA/RNA Synthesis
T74631	RNA polymerase II-IN-2
	RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α...
T74630	RNA polymerase II-IN-1		DNA/RNA Synthesis
	RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells...		DNA/RNA Synthesis
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T79923	T7 RNA polymerase		DNA/RNA Synthesis
	T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription (IVT) of mRNA. This polymerase requires Mg 2+ and selects on...		DNA/RNA Synthesis
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T6446	Clevudine	L-FMAU,Levovir	HBV , DNA/RNA Synthesis
	Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...		HBV , DNA/RNA Synthesis
T0220	Foscarnet sodium	Phosphonoformate	Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.		Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T6194	Fidaxomicin	Tiacumicin B,OPT-80,Clostomicin B1,PAR-101	Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme el...		Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic
T8972	FIT-039		Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...		Others , DNA/RNA Synthesis , CDK , HSV
T10104	3,4-Dihydroxybenzylamine hydrobromide	NSC 263475 hydrobromide	Others , DNA/RNA Synthesis
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activit...		Others , DNA/RNA Synthesis
T8841	IMT1	Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others , DNA/RNA Synthesis , Mitochondrial Metabolism
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.		Others , DNA/RNA Synthesis , Mitochondrial Metabolism
T0964	Floxuridine	5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis , Nucleoside Antimetabolite/Analog , Others , DNA/RNA Synthesis , Antibacterial , HSV
	Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T8842	IMT1B	3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others , DNA/RNA Synthesis
	IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it...		Others , DNA/RNA Synthesis
T3376	Cynaroside	Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,Luteolin 7-glucoside	Others , Influenza Virus , DNA/RNA Synthesis
	Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.		Others , Influenza Virus , DNA/RNA Synthesis
T9051	ZYN57939	MTR-106	DNA/RNA Synthesis
	ZYN57939 (MTR-106) is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.		DNA/RNA Synthesis
T10493	Beclabuvir	BMS-791325	Others
	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).		Others
T4356	POL1-IN-1	Compound 3A	DNA/RNA Synthesis
	POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.		DNA/RNA Synthesis